Hi Om's , For some Amateurradio programs you need a special driver to run it. Windows update sometimes to a new driver but you're program will not work or communicate to you're radio anymore. On this page my tested Drivers.
Prolific Driver for communicate with trancievers. when windows update this. commport will not work anymore. Version 18.104.22.168 will fix it. check commport wich driver it's use and replace with this one.